WEP Clinical is a global organisation and possesses all necessary licenses required to meet drug access and distribution needs across all regions, worldwide. BTG Specialty Solutions CenterTM is a trademark of BTG International Ltd. Ⓒ 2019 BTG International Inc. All rights reserved. BTG International Inc. 2012. de Miguel D, García-Suárez J Martín Y, Gil-Fernández JJ, Burgaleta C. Severe acute renal failure following high-dose methotrexate therapy in adults with haematological malignancies: a significant number result from unrecognized co-administration of several drugs. Durham, NC. Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome. WEP will utilize its expertise in Named Patient medicine supply to distribute this much-needed drug to patients within the EU as an unlicensed medicine. 3. Murashima M, et al. WEP Clinical (WEP) announced today that it has entered into a partnership with BTG Specialty Pharmaceuticals (BTG), a division of Boston Scientific. Oncologist. BTG International Inc; 2013. Ramsey L, Balis FM, O’Brien MM, et al. Consensus guidelines for use recommend administration of Voraxaze® at 48 hours following initiation of high-dose methotrexate (HDMTX) therapy when MTX concentrations are above 5 μM (2.27 μg/mL) and the serum creatinine is elevated relative to the baseline measurement. US-VRX-1900083 October 2019. Our priority is to protect and aid the health and safety of our employees, our customers and their patients. It also means finding new and creative ways to support the frontline healthcare providers working tirelessly to address the COVID-19 pandemic. Ther Clin Risk Manag. 2010; 28:3979-3986. Voraxaze® is approved in the USA and is the first and only drug approved to reduce toxic plasma methotrexate levels. BTG Specialty Pharmaceuticals. For related questions regarding DigiFab ®, please contact the BTG Specialty Solutions Center ™ at 1-844-293-0007, or email [email protected] To report suspected adverse reactions, contact BTG at 1-877-377-3784 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Green JM. https://www.nccn.org/professionals/physician_gls/default.aspx. Under the terms of the partnership, WEP will manage the exclusive distribution of BTG’s rescue medicine, Voraxaze® (glucarpidase), in the UK, European Union (EU) and European Economic Area (EEA) market. Serious hypersensitivity reactions occurred in less than 1% of patients, Methotrexate concentrations within 48 hours following Voraxaze, In clinical trials, the most common related adverse events (occurring in >1% of patients) were paresthesia, flushing, nausea and/or vomiting, hypotension and headache. 2012;8:403-4. Voraxaze® is a carboxypeptidase which breaks down methotrexate into active metabolites which are then eliminated from the body through organs other than the kidney (primarily the liver). Oncologist. Sep 2018 – Present 1 year 11 months. Our priority is to protect and aid the health and safety of our employees, our customers and their patients. Glucarpidase to combat toxic levels of methotrexate in patients. BTG Specialty Pharmaceuticals, a division of Boston Scientific (NYSE:BSX), today announced the European Medicines Agency (EMA) has accepted for review a Marketing Authorisation Application (MAA) for Voraxaze® (glucarpidase). How BTG Specialty Pharmaceuticals is Responding to the COVID-19 pandemic. BTG International Inc. 300 Four Falls Center Suite 300 300 Conshohocken State Road West Conshohocken, PA 19428 USA. 2018;71(3):314-325. Find out more about how we use your information in our Privacy Policy and Cookie Policy. Dart RC, Goldfrank LR, Erstad BL, et al. Conshohocken, Pennsylvania, United States. BTG Specialty Pharmaceuticals, a division of Boston Scientific, provides rescue medicines typically used in emergency rooms and intensive care units to treat patients for whom there are limited treatment options. That means ensuring our vital products are available when needed. Early and rapid reduction of methotrexate (MTX) concentrations can lower the risk of irreversible damage. 2. Widemann BC, Balis FM, Kempf-Bielack B, et al. 2018-2019 targeted medication safety best practices for hospitals. Accessed July 24, 2019. Beyond 48 to 60 hours, life-threatening toxicities and even death may not be preventable. 4. Preventing and managing toxicities of high-dose methotrexate. Ann Emerg Med. Expert Consensus Guidelines published in 2018 recommend that all hospitals that provide emergency care should stock 5 vials of Voraxaze®, The Institute for Safe Medication Practices (ISMP) recommends that all appropriate antidotes should be readily available, Standardized protocols and/or a coupled order should be set in place that permit the emergency administration of all appropriate antidotes used in the facility, Serious hypersensitivity reactions, including anaphylactic reactions, may occur. Widemann BC, Balis FM, Kim A, et al. To enable Verizon Media and our partners to process your personal data select 'I agree', or select 'Manage settings' for more information and to manage your choices. Data on file. Our priority is to protect and aid the health and safety of our employees, our customers and their patients. https://www.ismp.org/sites/default/files/attachments/2019-01/TMSBP-for-Hospitalsv2.pdf. Jahnke K, Korfel A, Martus P, et al; on behalf of the German Primary Central Nervous System Lymphoma Study Group (G-PCNSL-SG). Bedford Laboratories; 2011. 2004;100:2222-2232. Effective clearance of methotrexate using high-flux hemodialysis membranes. Service Desk Specialist Arraya Solutions. We are dedicated to the development, manufacture, and commercialization of quality medicines that make a real difference to patients and their families. Methotrexate clearance by high-flux hemodialysis and peritoneal dialysis: a case report. That means ensuring our vital products are available when needed. BTG and the BTG roundel logo are registered trademarks of BTG International Ltd. Voraxaze® is a registered trademark of Protherics Medicines Development Ltd., a BTG International group company. That means ensuring our vital products are available when needed. High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma. --BTG Specialty Pharmaceuticals, a division of Boston Scientific, today announced the European Medicines Agency has accepted for review a Marketing Authorisation Application for Voraxaze ®. Nephrol Dial Transplant. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. “This partnership with BTG fully demonstrates WEP Clinical’s commitment to supporting industry in making life-saving treatments available to patients in need around the world”, said Jas Khera, Managing Director EU, WEP Clinical. May 2017 – Sep 2018 1 year 5 months. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. http://www.pbm.va.gov/clinicalguidance/drugmonographs/Glucarpidase_ Drug_Monograph_and_Considerations_for_Use.doc. 2008;23:3762-3766. Established in 2008, WEP is a specialist pharmaceutical services company that works with sponsors to help patients and physicians gain access to medicines when there is no treatment available in their country.
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